论文部分内容阅读
目的 探讨肝炎后门脉高压性胃病 (PHG)发病机制、门脉高压时肠道菌群的分布以及与内毒素之间的关系、药物治疗对肠道菌群和内毒素的影响。方法 选择 2 0 0 2 - 0 2～ 2 0 0 3- 12大连市第六人民医院住院的肝炎后肝硬化及门脉高压性胃病患者 ,均做电子胃镜、治疗前后大便菌群分析、鲎实验检测血浆内毒素 (LPS)。结果 门脉高压胃病组与肝炎后肝硬化组和对照组相比较 ,拟杆菌、双歧杆菌显著减少 ;而肠杆菌科细菌、酵母菌显著增加。门脉高压胃病组与肝炎后肝硬化组血内毒素较对照组均显著增加 (P <0 0 1)。结论 内毒素与肠道菌群产生异常变化可能对门脉高压性胃病的发病有直接或间接的影响。
Objective To investigate the pathogenesis of posterior portal hypertensive gastropathy (PHG) in hepatitis, the distribution of intestinal microflora in portal hypertension and its relationship with endotoxin, and the effect of drug treatment on intestinal microflora and endotoxin. Methods: The patients with posthepatitic cirrhosis and portal hypertensive gastropathy who were hospitalized in Dalian Sixth People’s Hospital from 2000-2002 to 2000-31 were treated with electronic endoscopy. The stool flora was analyzed before and after treatment Plasma endotoxin (LPS) was detected. Results Compared with the post-hepatitis cirrhosis group and the control group, the numbers of Bacteroides and Bifidobacteria were significantly decreased in the group of portal hypertensive gastropathy and the number of Enterobacteriaceae and yeast was significantly increased. The levels of endotoxin in portal hypertensive gastropathy group and cirrhosis group were significantly higher than those in control group (P <0.01). Conclusion The abnormal changes of endotoxin and intestinal flora may have a direct or indirect impact on the incidence of portal hypertensive gastropathy.