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目的探讨家栖鼠对抗凝血灭鼠剂的抗药性变化。方法按全国鼠类抗药性监测协作组统一方法,进行无选择性摄毒试验。结果经对广州市所辖9区内捕获的130只褐家鼠、31只黄胸鼠、18只小家鼠进行抗药性监测,其抗性率分别为8.5%、45.2%和27.8%,总平均摄药剂量分别为17.72、278.46和1164.24mg/kg,按家栖鼠抗药性检验标准,黄胸鼠和小家鼠对第一代抗凝血剂杀鼠灵已形成抗药性种群,褐家鼠有抗药性个体产生。结论以黄胸鼠和小家鼠为优势种的场所,要考虑使用第二代抗凝血灭鼠剂;以褐家鼠为主的场所,则可继续使用第一代抗凝血灭鼠剂,但应加强对灭鼠药物的敏感性监测,科学、合理用药。
Objective To investigate the resistance of domestic rats to anticoagulant rodenticides. Methods According to the unified method of the National Collaborating Group on Resistance Investigation of Rodents, a non-selective toxicity test was conducted. Results The drug resistance of 130 Rattus norvegicus, 31 Rattus flavipectus and 18 Rattus norvegicus captured in 9 districts of Guangzhou were tested. The resistance rates were 8.5%, 45.2% and 27.8% The average dose was 17.72,278.46 and 1164.24mg / kg, respectively. According to the standard test of drug resistance in domestic animals, Rattus flavipectus and Mus musculus had formed resistant populations to the first-generation anti-coagulant warfarin, Murine resistant individuals develop. Conclusion The dominant species of Rattus flavipectus and Mus musculus are considered as the second generation of anticoagulant rodenticides. The first generation of anticoagulant rodenticides , But should strengthen the sensitivity of rodent control drug monitoring, scientific and rational drug use.