【摘 要】
：
Cooking oil fumes (COF) are one of the most common air pollutants in indoor living environments in China. When oil is heated above 250 ℃, at least 220 types of products are produced in the lampblack, including carcinogenic heterocyclic amines and B[α]P[1]
【机 构】
：
School of Public Health,Weifang Medical University,Weifang 261053,Shandong,China;Public Health Testi
论文部分内容阅读
Cooking oil fumes (COF) are one of the most common air pollutants in indoor living environments in China. When oil is heated above 250 ℃, at least 220 types of products are produced in the lampblack, including carcinogenic heterocyclic amines and B[α]P[1]. These agents can lead to the occurrence and development of cancer[2]. Previous studies have reported that exposure of lung epithelial cells to COF increases lipid peroxidation and oxidative stress[3]. A meta-analysis has indicated that COF exposure, notably in the absence of a fume extractor, may increase the risk of lung cancer among Chinese nonsmoking women[4]. Previous experiments have also shown that COF-derived components induce oxidative stress, apoptosis and inflammation in A549 cells and BEAS-2B cells, whereas this effect is prevented by vitamin C and N-acetylcysteine[5]. The antioxidant effects of vitamin C have been demonstrated in several in vitro models. The aim of the present study was to investigate the adverse effects of COF in lung tissues and the protective effects of vitamin C in mice after sub-acute exposure to different doses of COF, to provide chronic toxicity testing data and a basis for further mechanistic studies. Collectively, this information could be used as a reference for the prevention and treatment of lung injury caused by COF.
其他文献
Objective This study aims to investigate the infection of Clonorchis sinensis (C. sinensis) in high-incidence areas of Hunan Province, China. The phylogenetic analysis of the C. sinensis species in the highly infected areas was carried out.Method Infectio
目的 提出一种基于卷积神经网络(convolutional neural network,CNN)的眼科光学相干断层成像(optical coherence tomography,OCT)图像自动分类方法,实现对视网膜OCT图像的自动分类,缓解人工诊断依赖医生的临床经验、费时费力等问题.方法 基于公开的数据集2014_BOE_Srinivasan构建了2个样本数据集.其中样本数据集一为仅对数据集中的图像进行预处理后裁剪,样本数据集二为对取出测试集后剩余图像的裁剪过程中引入随机平移和水平翻转技术对图像进行扩
Beryllium (Be) is a non-radioactive element with carcinogenic properties, and presents serious occupational and environmental hazards from its resulting toxicants, which could significantly impact the health of the occupational population[1-3]. Beryllium
Objective Previous studies have shown that meteorological factors may increase COVID-19 mortality, likely due to the increased transmission of the virus. However, this could also be related to an increased infection fatality rate (IFR). We investigated th
“一口叙说千古事,双手对舞西万兵.”扯一块白布便是舞台,尺把小人演绎华彩.当青灯之影穿透人物、花草、楼宇……声色犬马、世间百态便在画幕的另一端映现,波澜壮阔的故事呈现于观众眼前,这就是皮影.两这精彩华丽的皮影,都是皮影手艺人一点点刀雕彩绘而成.在山西的“皮影之乡”孝义,就有一位身残却心巧的皮影制作工艺美术大师胡发伟,沿袭着千年来皮影的传统雕刻手法,矢志不移,匠心传承,让这一古老技艺重放光彩.
Low birth weight (LBW) is defined as a birth weight of less than 2,500 g. It has been estimated that 15％–20％ of infants (more than 20 million worldwide) were born with LBW, and 95.6％ of the overall LBW infants were born in low and middle income countries[
目的 针对像素间的领域结构信息难以获取,无法分析医学设备图像子块相似性的问题,本文提出了一种新的非局部相似性压缩感知下的医学设备三维成像方法.方法 首先获取医学设备三维图像并对其分块处理,通过冗余字典完成稀疏图像表示,利用自回归模型模拟医学设备三维成像的非局部状态,分析三维成像的非局部相似特性,得到医学设备三维图像的局部相关性和非局部相似性,以此为限定条件,实现医学设备三维成像的相似性压缩感知.最后以某三甲医院肿瘤科的3台医疗器械为实验对象,以不同时间段产生的三维图像为实验样本,与其他两种文献方法进行了对
In previous decades, people were concerned about their health because of growing environmental influences. The advancements in pulsed power technologies have increased the availability of microwave transmitters. The possible health problems caused by the
目的 核糖核酸(ribonucleic acid,RNA)在许多生命过程中起着关键作用,它几乎参与了遗传信息转录和翻译的各个方面.镁离子(Mg2+)是RNA折叠成稳定三级结构所必需的,而且常常与核酶的催化活性有关.尽管实验解析的RNA结构越来越多,但实验确定RNA结构中的离子存在诸多困难.三维卷积神经网络(three-dimensional convolutional neural network,3D-CNN)能够直接从原始数据中学习有用的特征,已被应用于一些基于结构的预测工作.为此本文拟提出一种基于3
目的 机械取栓术(mechanical thrombectomy,MT)是治疗急性缺血性脑卒中(acute ischemic stroke,AIS)的有效方法,治疗中使用的封闭式取栓支架的结构及力学特性对手术效果有重要影响.为了提高取栓支架的安全性及有效性,本研究对封闭式取栓支架的压握入管、自膨胀释放和迁移取栓3个阶段进行生物力学研究,分析取栓支架结构及其力学特征.方法 首先建立支撑单元个数不同(3、4、5)的B3、B4和B5取栓支架的几何模型,然后建立压握工具、模拟血管和血栓的有限元模型.在压握工具的径