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作者考察了单剂量及重复用药时,阿司匹林、别嘌呤醇及氨苄青霉素对氨酰心安动力学及药效的影响。受试者为6名健康成人,年龄25～30岁。分别单用氨酰心安或与阿司匹林等并用,剂量:氨酰心安100mg,阿司匹林500mg,别嘌呤醇300mg,氨苄青霉素1g。除氨苄青霉素外,阿司匹林与别嘌呤醇对氨酰心安的动力学及药效均无影响。单剂量给药后,氨酰心安的最高血浆浓度(Cmax)为511±59ng/ml,并用氨苄青霉素后,Cmax降至344±33ng/ml;曲线下面积从5818±476降至3459±303ng/ml/h;生物利用度
The authors investigated the effects of aspirin, allopurinol and ampicillin on the kinetics and pharmacodynamics of atenolol in single-dose and repeated doses. The subjects were 6 healthy adults, aged 25 to 30 years. Respectively with atenolol alone or with aspirin, etc., the dose: atenolol 100mg, aspirin 500mg, allopurinol 300mg, ampicillin 1g. In addition to ampicillin, aspirin and allopurinol had no effect on the kinetics and efficacy of atenolol. After single-dose administration, the maximum plasma concentration (Cmax) of atenolol was 511 ± 59 ng / ml and decreased to 344 ± 33 ng / ml with ampicillin; the area under the curve decreased from 5818 ± 476 to 3459 ± 303 ng / ml / h; bioavailability