为了探讨性别对螨胺磷代谢的影响 ,选用 SD大鼠 ,尾静脉注射染毒后 ,运用高效液相色谱 (HPL C)测定了螨胺磷分别在雌雄两种性别动物血液中的浓度经时变化 ,经拟合求得其代谢参数 ,发现 AUC雄 =32 1.10 (μg· m in/ml) ,AUC雌 =5 6 1.94(μg· m in/ ml) ;Cl (s)雄 =3.17× 10 - 2 ml/ m in,Cl (s)雌 =1.80× 10 - 2 ml/ min。两个参数在雌雄大鼠中的差异具有显著性意义 (P<0 .0 5 )。结果表明螨胺磷的代谢受性别影响 ,在雄性大鼠中更容易被清除。 In order to investigate the effect of sex on the metabolism of mite, the SD rats were selected and injected intravenously by tail vein to determine the concentration of mite in the blood of both sexes after high-performance liquid chromatography (HPL C) (AUC) = 32 1.10 (μg · m in / ml), AUC female = 56.194 (μg · m in / ml); Cl (s) male = 3.17 × 10 - 2 ml / m in, Cl (s) female = 1.80 × 10 -2 ml / min. The difference of the two parameters in male and female rats was significant (P <0.05). The results showed that the metabolism of mite is affected by gender and is more easily cleared in male rats.