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目的探讨阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的临床疗效及其安全性。方法选择2010年6月—2016年7月于凭祥市人民医院收治的肺炎支原体肺炎患儿70例,随机将其分为两组,即对照组(35例)和观察组(35例),两组患儿均给予基础治疗和相关护理,对照组患儿给予头孢呋辛钠序贯疗法进行治疗,观察组患儿给予阿奇霉素序贯疗法进行治疗,对比两组患儿的临床疗效、症状缓解情况、炎性因子水平以及不良反应发生情况。结果对照组治疗总有效率为85.7%,观察组为97.1%,观察组治疗总有效率明显高于对照组(P<0.05);相较于对照组,观察组患儿咳嗽消失时间、退热时间、肺部湿啰音消失时间以及胸片恢复正常时间均明显缩短(P<0.05);治疗后,两组患儿的超敏C反应蛋白水平较治疗前均有一定程度的下降,且观察组患儿明显低于对照组(P<0.05);观察组不良反应发生率明显低于对照组,两组比较差异均有统计学意义(P<0.05)。结论阿奇霉素序贯疗法治疗小儿支原体肺炎的临床疗效确切,可有效改善患儿的临床症状,缩短住院时间,安全性高。
Objective To investigate the clinical efficacy and safety of sequential treatment of azithromycin in children with Mycoplasma pneumoniae pneumonia. Methods Seventy patients with Mycoplasma pneumoniae pneumonia admitted in Pingxiang People’s Hospital from June 2010 to July 2016 were randomly divided into two groups: control group (35 cases) and observation group (35 cases) Two groups of children were given basic treatment and related care, the control group were given sequential treatment of cefuroxime sodium treatment, the observation group were treated with azithromycin sequential therapy, compared the clinical efficacy of the two groups of children, symptoms were relieved Conditions, levels of inflammatory cytokines and the incidence of adverse reactions. Results The total effective rate was 85.7% in the control group and 97.1% in the observation group. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). Compared with the control group, the disappearance of cough in the observation group, Time, the disappearance time of pulmonary wet rales and the time to normal chest radiograph were all significantly shortened (P <0.05). After treatment, the levels of hypersensitive C-reactive protein in both groups decreased to a certain extent compared with before treatment The incidence of adverse reactions in the observation group was significantly lower than that in the control group, with significant difference between the two groups (P <0.05). Conclusion Sequential azithromycin treatment of children with mycoplasma pneumonia clinical curative effect is exact, can effectively improve children’s clinical symptoms, shorten the hospital stay, high safety.