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目的 观察妊娠期和哺乳期胃幽门部生长抑素 (SS)免疫反应阳性细胞 (D细胞 )的变化。 方法 应用免疫细胞化学和放射免疫方法测定胃幽门粘膜生长抑素阳性细胞染色强度、数密度 (NV)、体密度 (VV)和面数密度 (NA)以及胃液内生长抑素含量。 结果 妊娠第 19天 ,D细胞染色强度、数密度、体密度和面数密度明显升高(P<0 .0 5 ) ;哺乳第 2 0天 ,D细胞染色明显减弱、数密度、体密度和面数密度显著下降 (P<0 .0 5 ) ,胃液内生长抑素含量明显增加 (P<0 .0 5 )。 结论 生长抑素参与妊娠、哺乳期胃肠功能的调节。
Objective To observe the changes of somatostatin (SS) immunoreactive positive cells (D cells) in the stomach pylorus during pregnancy and lactation. Methods Immunocytochemistry and radioimmunoassay were used to determine the staining intensity, number density (NV), body density (VV) and number density (NA) of gastric somatostatin-positive cells and somatostatin content in gastric juice. Results Dye staining intensity, number density, body density and number density of D cells were significantly increased on the 19th day of gestation (P <0.05). On the 20th day of lactation, the staining of D cells was obviously weakened. The number density, body density and (P <0.05). The content of somatostatin in gastric juice significantly increased (P <0.05). Conclusion Somatostatin is involved in the regulation of gastrointestinal function during pregnancy and lactation.