Diagnosis and management of interstitial pneumonitis associated with interferon therapy for chronic

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:tianzhiziyao
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Interstitial pneumonitis(IP) is an uncommon pulmonary complication associated with interferon(IFN) therapy for chronic hepatitis C virus(HCV) infection.Pneumonitis can occur at any stage of HCV treatment,ranging from 2 to 48 wk,usually in the first 12 wk.Its most common symptoms are dyspnoea,dry cough,fever,fatigue,arthralgia or myalgia,and anorexia,which are reversible in most cases after cessation of IFN therapy with a mean subsequent recovery time of 7.5 wk.Bronchoalveolar lavage in combination with chest high resolution computed tomography has a high diagnostic value.Prompt discontinuation of medication is the cornerstone,and corticosteroid therapy may not be essential for patients with mild-moderate pulmonary functional impairment.The severity of pulmonary injury is associated with the rapid development of IP.We suggest that methylprednisolone pulse therapy followed by low dose prednisolone for a short term is necessary to minimize the risk of fatal pulmonary damage if signs of significant pulmonary toxicity occur in earlier stage.Clinicians should be aware of the potential pulmonary complication related to the drug,so that an early and opportune diagnosis can be made. Interstitial pneumonitis (IP) is an uncommon pulmonary complication associated with interferon (IFN) therapy for chronic hepatitis C virus (HCV) infection. .Its most common symptoms are dyspnoea, dry cough, fever, fatigue, arthralgia or myalgia, and anorexia, which are reversible in most cases after cessation of IFN therapy with a mean subsequent recovery time of 7.5 wk.Bronchoalveolar lavage in combination with chest high resolution computed tomography has a high diagnostic value. Prompt discontinuation of medication is the cornerstone, and corticosteroid therapy may not be essential for patients with mild-moderate pulmonary functional impairment. severity of pulmonary injury is associated with the rapid development of IP.We suggest that methylprednisolone pulse therapy followed by low dose prednisolone for a short term is necessary to minimize the risk of fatal pulmonary damage if signs of si gnificant pulmonary toxicity occur in earlier stage. Clinicians should be aware of the potential pulmonary complication related to the drug, so that an early and opportune diagnosis can be made.
其他文献
2014年10月22日,“我的国学我的价值观”天津市大中专学生培育和践行社会主义核心价值观活动校园启动仪式暨“对话·我的价值观”高峰访谈在天津大学举行。共青团天津市委员
微信小程序迷人的部分,并不是它为应用开发者创造了更多的创业机会,而是带来了一条来自未来的讯息:无论是产品还是内容,它的载体都需要为了用户更易获取不断变小变轻,直至消
1 When China Ruled the Seas:The Treasure Fleet of the Dragon Throne,1405-1433《当中国称雄海上》Author:Louise Levathes Publisher:Oxford University Press“A livel
《对联》杂志社北京编辑部今年第五期卷首语,发布《选用稿件试行标准》的说明,我认为较客观。它不仅是采用稿件的原则,也是指导怎样来写的方向。写出的稿件(各种 “UF” mag
兴趣是最好的老师,数学教学亦是如此?那么如何培养学生的兴趣呢?教师十分重视的一个问题。俄国大教育家乌申斯基指出:“没有丝毫兴趣的强制性学习,将会扼杀学生探求真理的欲
几乎是一眨眼的工夫,《曲艺》杂志创刊五十年了。我也咯噔一下儿长到了“古稀”之年的边缘,再向前蹭几尺就是真正的老年了,怪吓人的。想当年,捧着一本刚出炉的《曲艺》杂志,
喜欢“宅”电影的朋友经常会搜索一些最新的影片信息,而且希望获得来自国外的信息,这样就往往需要使用英文的关键词进行搜索。如果每次搜索前先翻译,既麻烦又浪费时间,而借助
请下载后查看,本文暂不支持在线获取查看简介。 Please download to view, this article does not support online access to view profile.
期刊
本研究采用SCL—90临床症状自评量表,随机整群抽取黑龙江中医学院和南京中医药大学本科大学生进行测试,与全国成人常模和综合大学学生对照分析,结果表明:中国大学生心理健康水平
1967年6月17日上午8时20分,我国西部地区新疆罗布泊上空,我国第一颗氢弹爆炸试验获得完全的成功,其爆炸威力,相当于美国当年投到日本广岛那颗原子弹的150多倍。震惊世界的蘑