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目的了解心房颤动(AF)患者射频消融术(RFCA)前后心肌生化标记物的变化。方法将32例AF患者按不同的术式分为3组:单纯环左右侧肺静脉电隔离术组(1组)、环左右侧肺静脉电隔离术联合心房线性消融术组(2组)、环左右侧肺静脉电隔离术联合碎裂电位消融术组(3组),分别比较其RFCA前后心肌生化标记物(肌红蛋白MYO,肌酸激酶同工酶CK-MB,心肌肌钙蛋白TNI)的变化。结果第1、2组患者的各项指标在RFCA前后的变化有统计学意义(p<0.05)。第3组患者除CK-MB在RFCA前后的变化没有统计学意义(p>0.05),其他各项指标的变化均具有统计学意义。3组患者RFCA后心肌生化标记物的差异无统计学意义(p>0.05)。结论 RFCA虽然对心肌组织造成一定的损伤,但是在环左右肺静脉电隔离术的基础上,增加心房线性消融或者碎裂电位消融并不会进一步加重心肌损伤。
Objective To investigate the changes of myocardial biochemical markers in patients with atrial fibrillation (AF) before and after radiofrequency ablation (RFCA). Methods 32 cases of AF patients were divided into three groups according to different surgical procedures: left and right pulmonary vein isolation group (group 1), left and right pulmonary vein isolation and atrial linear ablation group (group 2) The changes of Myocardial biochemical markers (myoglobin MYO, creatine kinase CK-MB and cardiac troponin TNI) before and after RFCA were compared among the groups (3 groups) . Results The indexes of group 1 and group 2 had significant changes before and after RFCA (p <0.05). The change of CK-MB in group 3 before and after RFCA was not statistically significant (p> 0.05), and the changes of other indexes were all statistically significant. There was no significant difference in myocardial biochemical markers after RFCA among 3 groups (p> 0.05). Conclusions Although RFCA may cause some damage to myocardial tissue, the addition of atrial linear ablation or fragmentation potential ablation does not further aggravate myocardial damage, based on the electrical isolation of the pulmonary vein around the ring.