抗癫痫药物的血药浓度与疗效和毒副反应密切相关。药物的治疗血浓度(如卡马西平6～10μg/ml,苯妥英10～20μg/ml,扑痫酮8～12μg/ml)和毒性浓度(如卡马西平>15μg/ml,苯妥英>25μg/ml,扑痫酮>15μg/ml)相近,用药剂量个体差异较大,临床上又常见几种抗癫痫药物同时使用,故有必要建立同时检测血药浓度的方法。由此逐步实现给药方案的合理化和用药剂量的个体化。 Antiepileptic drug plasma concentration and efficacy and toxicity are closely related. (Eg carbamazepine> 15μg / ml, phenytoin> 25μg / ml), the therapeutic blood concentration of the drug (eg 6-10μg / ml of carbamazepine, 10-20μg / ml of phenytoin and 8-12μg / ml of epilepsy ketone) , Epilepsy ketone> 15μg / ml) similar dose of individual differences in the larger, clinical and common use of several anti-epileptic drugs, it is necessary to establish a method of simultaneous detection of plasma concentrations. Therefore, the rationalization of dosage regimen and the individualization of dosage are gradually realized.