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背景:F波最短潜伏期和传导速度已广泛应用于各种神经病变的检测。然而,F波的其他参数的意义和诊断评估价值较少见报道,其对提高糖尿病周围神经病早期评估敏感性如何?目的:探讨F波各参数在糖尿病周围神经病的早期评估意义。设计:以2型糖尿病患者和健康人为研究对象的病例-对照研究。单位:武汉大学人民医院神经科和内分泌科病房和门诊。对象:糖尿病组为1999-01/2000-12武汉大学人民医院神经科和内分泌科就诊的2型糖尿病患者106例,男64例,女42例,平均(55±13)岁;糖尿病平均病程(10.2±4.8)年。正常对照组为75例健康志愿者,男45例,女30例,平均年龄(54±12)岁。两组间年龄、腿长匹配(P>0.05)。干预:以Nicolet-VikingIV肌电图仪,对糖尿病组和对照组胫神经进行F波测定;同时记录M波。主要观察指标:①2型糖尿病患者和正常人F波最短潜伏期(Fmin)、时限(Fdur)、波幅(Famp)和面积(Farea);M波负峰波幅(Mamp)和面积(Marea)的差异。②有无神经病变及不同病变程度2型糖尿病患者异常胫神经F波分布情况。结果:①对照组Fmin上限(Y)与腿长(X)的函数关系为Y=12.3+48.8X2。②无神经病变患者组(n=30)Fdur增宽8例(异常率27%)、Fmin延长4例(13%)、F/Marea增大2例。③与对照组比较,有神经病变患者组(n=76)Fmin延长,F/Mamp及F/Marea
Background: F wave minimum latency and conduction velocity have been widely used in the detection of various neuropathies. However, the significance and diagnostic value of other parameters of F-wave are seldom reported and their sensitivity to improve the early assessment of diabetic peripheral neuropathy is poor. OBJECTIVE: To investigate the significance of F wave parameters in the early assessment of diabetic peripheral neuropathy. Design: A case-control study of type 2 diabetes and healthy individuals. Unit: People’s Hospital of Wuhan University Neurology and Endocrinology wards and clinics. PARTICIPANTS: A total of 106 patients with type 2 diabetes who were treated in Department of Neurology and Endocrinology, People’s Hospital of Wuhan University from January 1999 to December 2000 were enrolled in this study. There were 64 males and 42 females with average age of (55 ± 13) years. The average course of diabetes mellitus 10.2 ± 4.8) years. The normal control group was 75 healthy volunteers, 45 males and 30 females, mean age (54 ± 12) years old. Two groups of age, leg length match (P> 0.05). Intervention: Nicolet-VikingIV electromyograph was used to measure the F wave in the tibial nerve of the diabetic group and the control group; at the same time, the M wave was recorded. MAIN OUTCOME MEASURES: ① Fmin, Fd and Farea of F wave and difference of M wave and Marea in type 2 diabetic patients and normal subjects. ② with or without neuropathy and varying degrees of diseased patients with type 2 diabetes abnormal tibial nerve F wave distribution. Results: ① The upper limit of Fmin (Y) and the function of leg length (X) in control group were Y = 12.3 + 48.8X2. (2) There were 8 patients with no neuropathy (n = 30), 8 patients with abnormal Fdur (27% abnormal rate), 4 patients (13%) with Fmin prolongation and 2 patients with F / Marea enlargement. ③ Compared with the control group, patients with neuropathy group (n = 76) had longer Fmin, F / Mamp and F / Marea