慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)为世界范围内的多发病、常见病,是目前引起慢性死亡的主要原因之一,已成为世界所有疾病中排名第4位的死因。COPD对家庭及社会的经济负担越来越重,预测2020年将位居全世界疾病经济负担第5位,逐渐成为全球范围内关注的健康问题[1]。COPD的发病机制至今尚未明确,国内外公认的主要有炎症机制,即气道、肺实质及肺血 Chronic Obstructive Pulmonary Disease (COPD), one of the most common causes of chronic death in the world, has become the fourth leading cause of death in all diseases in the world. COPD has become more and more important to the family and society. It is predicted that by the year 2005, the fifth place in the world for the economic burden of disease will gradually become the health issue of concern worldwide [1]. The pathogenesis of COPD is still not yet clear, the main recognized inflammatory mechanisms at home and abroad, namely, airways, lung parenchyma and pulmonary blood