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目的研究低效价肝素对内皮细胞增殖过氧化的影响及对其损伤的保护作用。方法比色法测定内皮细胞的增殖。结果在培养液中含内皮细胞生长因子（６０ｍｇ／Ｌ）时，低效价肝素能显著刺激内皮细胞增殖，其作用呈浓度依赖关系；同时发现，脂质过氧化造成培养上清液中ＬＤＨ漏出量增加，低效价肝素能显著降低培养上清液中ＬＤＨ的漏出量。结论低效价肝素具有保护血管内皮细胞的作用。
Objective To investigate the effect of low titer heparin on endothelial cell proliferation and the protective effect of its damage. Methods Colorimetry was used to determine the proliferation of endothelial cells. Results When the culture medium containing endothelial cell growth factor (60mg / L), low titer of heparin can significantly stimulate endothelial cell proliferation, its role in a concentration-dependent manner; also found that lipid peroxidation caused LDH leakage in the culture supernatant Increasing the amount of low potency heparin can significantly reduce LDH leakage in the culture supernatant. Conclusion Low potency heparin protects vascular endothelial cells.