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目的探讨5-羟色胺(5-HT)在支气管哮喘(下称哮喘)豚鼠气道重塑中的作用机制。方法将50只雄性豚鼠随机分为正常对照组(A组)、哮喘模型组(B组)、哮喘模型延续组(B1组)、5-HT组(B2组)、5-HT拮抗剂组(B3组)。用卵清蛋白复制哮喘气道重塑模型。观察血清5-HT浓度和气道壁各层厚度。结果①血清5-HT浓度与气道壁各层厚度B组明显大于A组,B1组明显大于B组,P<0.05,<0.01。②气道壁各层厚度B2组大于B1组,B3组小于B1组,P均<0.05。结论5-HT浓度变化是哮喘豚鼠气道重塑的机制之一。
Objective To investigate the mechanism of 5-hydroxytryptamine (5-HT) in airway remodeling in bronchial asthma (asthmatic) guinea pigs. Methods Fifty male guinea pigs were randomly divided into normal control group (group A), asthma model group (group B), asthma model continuation group (group B1), 5-HT group (group B2) and 5-HT antagonist group B3 group). Ovalbumin replicates asthma airway remodeling model. Serum 5-HT concentration and airway wall thickness were observed. Results ① Serum 5-HT concentration and thickness of airway wall in group B were significantly higher than those in group A, while those in group B1 were significantly greater than those in group B (P <0.05, <0.01). ② The thickness of airway wall B2 group was larger than B1 group, B3 group was smaller than B1 group, P <0.05. Conclusion The change of 5-HT concentration is one of the mechanisms of airway remodeling in asthmatic guinea pigs.