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背景冠心病的主要独立危险因素包括性别、吸烟、高血压、高脂血症、糖尿病和老年等,但仅约50%的冠心病患者存在这些传统的危险因素,确立冠心病其他危险因素的必要性显得越来越突出。目的研究新疆地区维吾尔族、汉族血浆同型半胱氨酸(homocysteine,Hcy)水平与冠心病的关系,探讨同型半胱氨酸在不同民族冠心病发病中的地位。设计以诊断为依据的病例对照研究。地点、对象和方法收集2001-10/2002-01新疆医科大学第一附属医院心内科住院并行冠状动脉造影术的110例患者,按冠状动脉造影结果分为冠状动脉狭窄组(n=74)与冠状动脉正常组(n=36),并用高效液相色谱法测定血浆同型半胱氨酸水平。结果冠状动脉狭窄组血浆Hcy水平(μmol/L)明显高于冠状动脉正常组(17.40±10.95和11.78±4.56;t=3.79,P<0.05),冠状动脉狭窄组中高Hcy血症占41%,高于冠状动脉正常组(14%),差异有显著性意义(χ2=6.75,P<0.01)。冠状动脉狭窄组汉族血浆Hcy水平(μmol/L)显著高于冠状动脉正常组汉族(18.40±11.86和12.36±5.17;q=3.65,P<0.05),冠状动脉狭窄组和冠状动脉正常组维吾尔族之间差异无显著性意义(q=1.34,P>0.05)。结论新疆地区冠心病患者血浆同型半胱氨酸水平明显升高,高同型半胱氨酸血症所占比例较大,而同型半胱氨酸对新疆地区冠心病患
Background The main independent risk factors for CHD include gender, smoking, hypertension, hyperlipidemia, diabetes and the elderly, but only about 50% of CHD patients have these traditional risk factors and the need to establish other risk factors for coronary heart disease Sex is more and more prominent. Objective To investigate the relationship between plasma homocysteine (Hcy) levels and coronary heart disease in Uygur and Han nationalities in Xinjiang and investigate the role of homocysteine in the pathogenesis of coronary heart disease of different ethnic groups. Case-control studies based on diagnosis were designed. Location, Subjects and Methods 110 patients undergoing coronary angiography in Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University from October 2001 to January 2002 were divided into coronary stenosis group (n = 74) and coronary artery stenosis group Coronary normal group (n = 36), and plasma homocysteine levels were determined by high performance liquid chromatography. Results The level of plasma homocysteine (μmol / L) in coronary artery stenosis group was significantly higher than that in normal coronary artery group (17.40 ± 10.95 vs 11.78 ± 4.56; t = 3.79, P <0.05) Higher than the normal coronary artery group (14%), the difference was significant (χ2 = 6.75, P <0.01). The Hcy level (μmol / L) in Han patients with coronary artery stenosis was significantly higher than that in Han subjects with normal coronary artery (18.40 ± 11.86 vs 12.36 ± 5.17; q = 3.65, P <0.05). In the coronary stenosis group and the normal Uighur group, There was no significant difference between the two groups (q = 1.34, P> 0.05). Conclusions Plasma homocysteine level is significantly elevated in patients with coronary heart disease in Xinjiang, with a high proportion of homocysteine. Homocysteine has a positive effect on coronary heart disease