目的　研究Ⅲ期乳腺癌术前新辅助化疗的临床效果。方法　 1999年～ 2 0 0 1年 6月住院手术治疗的Ш期乳腺癌患者 62例 ,术前行辅助化疗 ,回顾分析 1997～ 1998年间收治的 3 7例Ш期乳腺癌未作辅助化疗而直接手术作为对照组。从手术切除后病理切片观察细胞变化及术后局部复发 ,远处转移等方面进行比较。结果　手术后病理切片观察癌细胞坏死情况 ,新辅助化疗组有效率为 67.7% ,而对照组仅 6例癌细胞有轻度局灶坏死。术后三年局部复发或远处转移新辅助化疗组为 11.4% ,对照组 2 4.3 %。结论　手术前辅助化疗能大量杀伤肿瘤细胞 ,缩小肿瘤便于手术 ,减少远处播散机会 Objective To study the clinical effect of neoadjuvant chemotherapy for stage Ⅲ breast cancer. Methods Sixty-two patients with stage Ⅲ breast cancer undergoing inpatient surgery during 1999-2001 were enrolled in this study. Adjuvant chemotherapy was performed preoperatively. A total of 37 7 cases of breast cancer admitted between 1997 and 1998 were treated without adjuvant chemotherapy Surgery as a control group. From the surgical resection of the pathological changes in cell observation and postoperative local recurrence, distant metastasis and other aspects were compared. Results The pathological changes of the cancer cells were observed after operation. The effective rate of the neoadjuvant chemotherapy group was 67.7%, while only 6 cases of the control group had mild focal necrosis. After three years of local recurrence or distant metastasis of neoadjuvant chemotherapy group was 11.4%, control group, 22.3%. Conclusions Preoperative adjuvant chemotherapy can kill large numbers of tumor cells, reduce the size of the tumor, facilitate the operation and reduce the chances of distant spread