【摘 要】
：
Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain.Inthomycin B (1) and its two new analogues 2 and 3 were iso
【机 构】
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State Key Laboratory of Phytochemistry and Plant Resources in West China, and CAS Center for Excelle
论文部分内容阅读
Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain.Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8.Identification of the gene cluster for inthomycin biosynthesis as well as the 15N-labeled glycine incorporation into inthomycins are described.Combined with the gene deletion of the rare P450 domain in the NRPS module,a formation mechanism of carboxamide moiety in inthomycins was proposed via an oxidative release of the assembly chain assisted by the P450 domain.
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