【摘 要】
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The characterization of the interacting behaviors of complex biological systems is a pri-mary objective in protein-protein network analysis and computational bi
【机 构】
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Department of Control and Computer Engineering
【出 处】
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基因组蛋白质组与生物信息学报(英文版)
论文部分内容阅读
The characterization of the interacting behaviors of complex biological systems is a pri-mary objective in protein-protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected pro-tein-protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in dis-eases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.
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