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近年来,三氧化二砷在白血病等各种恶性肿瘤治疗的基础研究和临床实践方面已取得了长足的进步。本文从其诱导肿瘤细胞凋亡、对癌细胞的靶向作用、对抑癌基因的去甲基化作用以及抑制肿瘤细胞生长和肿瘤新生血管形成等方面对三氧化二砷抗癌作用机制的研究进展进行综述。
In recent years, arsenic trioxide has made great strides in the basic research and clinical practice in the treatment of various malignancies such as leukemia. This review summarizes the mechanism of anti-cancer effect of arsenic trioxide in the aspects of inducing tumor cell apoptosis, targeting effect on cancer cells, demethylating effect of tumor suppressor gene, inhibiting tumor cell growth and tumor angiogenesis .