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目的：研究空肠弯曲菌(Cj)的主要外膜蛋白(momp)基因的分子分型。方法：采用PCR方法对163株空肠弯曲菌的主要外膜蛋白基因进行扩增，用HindⅢ，HaeⅢ，MboⅡ和HhaI四种内切酶消化后进行电泳分析，并与热稳定性血清型(HS)和鞭毛蛋白A基因(flagellin A gene，fal A)分型方法相比较。结果：共观察到8种不同的主要外膜蛋白的限制性片段长度多态性的基因型，其中主要外膜蛋白基因-3(momp-3)占61％。Guillain-Barré综合征(GBS)和腹泻患者所有34株HS-19:Cj(fla)-1菌株均属同一个单一基因型，即主要外膜蛋白基因-1(momp-1)。结论：HS-19：Cj(fla)-1:momp-1菌株是空肠弯曲菌的一个特殊类型，与HS-19相关的GBS可能是阐明GBS发病机制最好的模型。“,”Objective: To study thd momecular typing of the major outer membrane protein gene(momp) of Campylobacter jejuni(C.jejuni). Methods: The C. jejuni major outer membrane protein gene was arnplified by PCR from a total of 163 strains. AfterHind Ⅲ , HaeⅢ, Mbo Ⅱ and HhaI restriction enzyme digestions, the digest was analyzed by electrophoresis, and then comparedwith heat-stable(HS) serotype and PCR-based restriction fragnent length polymorphism(RFLP) typing of flagellin A gene (flaA). Results: Eight distinct momp RFLP genotypes were observed. Among all of them, one major type (momp-3) accounted for61% of all isolates. All 34 HS-19:Cj(fla)-1 strains,including isolates from patients with Guillain-Barré syndrome(GBS) and en-teritis,belonged to a single genotype(momp-1). Conclusion: The HS-19:Cj(fla)-1 :momp-1 strain is distinctive among C.jejunistains,and HS-19 related GBS may be an excellent model to elucidate the pathogenesis of GBS.