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目的:探讨外科显微手术切除联合瘤床内植入5-氟尿嘧啶(5-FU)多聚缓释体局部化疗和125I局部放疗治疗胶质瘤的疗效。方法:65例胶质瘤行开颅显微手术切除,术中瘤床周围植入5-FU多聚缓释体和125I粒子,术后每3个月立体定向引导再次植入1～2次。观察疗效和瘤周水肿情况及不良反应。结果:术后1周内头痛明显,脑脊液白细胞不同程度的升高,瘤周水肿较单纯手术明显,经治疗所有患者都顺利出院。随访6个月～5年,39例患者获完全随访;患者生存36例。结论:手术切除肿瘤联合瘤床内植入缓释5-FU多聚缓释体局部化疗和125I局部放疗,是治疗胶质瘤的一种有效地方法。
Objective: To investigate the effect of surgical microsurgical resection combined with implantation of 5-fluorouracil (5-FU) polymerized sustained release local chemotherapy and 125I local radiotherapy in glioma. Methods: 65 cases of glioma underwent craniotomy microsurgical resection, implantation of 5-FU polymeric sustained-release body and 125I particles around the tumor bed in operation, and stereotactic guidance was re-implanted once or twice every 3 months after operation . Observation of efficacy and peritumoral edema and adverse reactions. Results: The headache was obvious within 1 week after operation. The leucocyte in cerebrospinal fluid increased to varying degrees. The peritumoral edema was more obvious than the simple operation. All the patients were discharged smoothly after treatment. All patients were followed up for 6 months to 5 years. All 39 patients were followed up completely. Patients survived 36 cases. CONCLUSIONS: Surgical resection of tumor combined with intratumoral implantation of sustained-release 5-FU multimeric sustained-release drug and 125I local radiotherapy is an effective method for the treatment of gliomas.