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目的和方法 :本研究运用多导睡眠描记 (PSG)方法、大白鼠开阔实验法及强迫游泳实验观察杏仁核的基底外侧核 (BLN)内微量注射谷氨酸、吗啡和纳络酮对大鼠睡眠、觉醒和行为的影响。结果 :用谷氨酸选择性兴奋BLN内神经元胞体可增加觉醒 ,减少慢波睡眠 (SWS)和总睡眠时间 (TST) ,增加大鼠自主活动和缩短强迫游泳“不动”时间。吗啡作用与谷氨酸相似 ,而阿片受体阻断剂纳络酮引起的作用则与之相反 ,并可完全阻断吗啡的作用。结论 :BLN神经元兴奋可引起觉醒增加、SWS减少和自主活动增加效应 ,阿片受体激动剂是BLN调节睡眠、觉醒和行为的重要递质。
PURPOSE AND METHODS: In this study, polysomnography, morphine and naloxone were administered to rats by means of polysomnography (PSG), open-ended test and forced swimming test in rats. Effects of sleep, wakefulness and behavior. Results: Selective activation of glutamate-induced neuronal somatic cells in BLN increased wakefulness, reduced SWS and TST, increased autonomic activity and shortened immobility time in forced swimming. Morphine acts similarly to glutamate, whereas the opioid receptor blocker naloxone causes the opposite effect and completely blocks the morphine effect. CONCLUSIONS: Excitability of BLN neurons causes increased awakening, decreased SWS and increased autonomic activity. Opioid receptor agonists are important mediators of BLN regulation of sleep, wakefulness and behavior.