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目的:优选复方金钱草胶囊中黄芪党参的提取工艺。方法:采用苯酚-硫酸法和HPLC-ELSD法,以多糖和黄芪甲苷为检测指标,采用正交设计试验进行提取工艺的优选。结果:筛选得到的最佳提取条件为:以水为提取溶剂,加10倍药材量溶剂,加热回流提取3次,每次1.5h。结论:经优选的工艺提取率高,合理可行,为复方金钱草胶囊的质量控制提供了方法,同时也为其工业化生产提供了依据。
Objective: To optimize extraction process of Radix Astragali Codonopsis Compound Compound Qiancao Capsule. Methods: Phenol-sulfuric acid method and HPLC-ELSD method were used to determine polysaccharides and astragaloside as the indexes. The orthogonal design was used to optimize the extraction process. Results: The optimal extraction conditions were as follows: water as the extraction solvent, plus 10 times the amount of solvent, heating reflux extraction three times, each time 1.5h. Conclusion: The extraction rate of the process is high, reasonable and feasible, which provides a method for the quality control of Compound Money Grass Capsules, and also provides a basis for its industrialized production.