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目的 :探讨养肺活血汤对肺纤维化大鼠血液流变性及体外血小板聚集的影响。方法 :以博莱霉素A5造成大鼠肺纤维化 ,用养肺活血汤临床等效剂量及临床 3倍量灌胃治疗 2 8天 ,观察其对模型大鼠血液流变性的改善作用 ;以ADP和AA作诱导剂 ,观察该方对血小板聚集率的影响。结果 :养肺活血汤能降低肺纤维化大鼠血液粘度 ,抑制红细胞变形能力的降低及体内、外血小板聚集率的增高
Objective: To explore the effect of Yangfeihuoxue decoction on hemorheology and in vitro platelet aggregation in pulmonary fibrosis rats. METHODS: Pulmonary fibrosis was induced by bleomycin A5 in rats. The clinical equivalent dose of Yangfei Huoxue Decoction and 3 times of clinical gavage treatment were used for 28 days to observe the effect of improving the hemorheology of model rats. ADP and AA were used as inducers to observe the effect of this side on platelet aggregation rate. Results : Yangfeihuoxue decoction can reduce the blood viscosity of rats with pulmonary fibrosis, inhibit the decrease of red blood cell deformability and increase the platelet aggregation rate in vivo and in vitro.