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目的提高局部晚期鼻癌的局部控制率及总生存率。方法78例局部晚期鼻咽癌患者随机分为放疗联合化疗增敏组(放化组)和单纯放疗组(单放组),两组放疗方法相同,放化组放疗同时给予顺铂(DDP)。结果随访3年肿瘤残存情况,放化组鼻咽部残存3例(7.9%),颈部残存3例(7.9%);单放组鼻咽部残存11例(27.5%),颈部残存2例(5.0%)。其中鼻咽部残存差异有统计学意义(P=0.024),颈部残存差异无统计学意义(P=0.602)。放化组局部复发4例(10.5%),单放组12例(30.0%),两组差异有统计学意义(P=0.033)。远处转移放化组11例(28.9%),单放组18例(45.0%),两组差异无统计学意义(P=0.143)。生存情况,放化组1、3年生存率为95.0%和74.8%,单放组为90.0%和59.5%,两组差异无统计学意义(P=0.168)。结论放疗合并使用DDP可减少肿瘤残存率,提高局部控制率。
Objective To improve the local control rate and overall survival rate of locally advanced nasopharyngeal carcinoma. Methods Seventy-eight patients with locally advanced nasopharyngeal carcinoma were randomly divided into radiotherapy combined with chemosensitization (radiotherapy group) and radiotherapy alone group (radiotherapy alone group). The radiotherapy methods were the same in both groups. Radiotherapy combined with cisplatin (DDP) . Results Three years follow-up of tumor remnant. Three cases (7.9%) were nasopharyngeal remnant and three cases (7.9%) remained nasopharyngeal in radiotherapy group. Nasopharyngeal remnant (11 cases, 27.5% Example (5.0%). There was significant difference in nasopharyngeal remnant (P = 0.024) and no significant difference in neck remnant (P = 0.602). There were 4 cases (10.5%) of local recurrence in radiotherapy group and 12 cases (30.0%) in radiotherapy group, the difference was statistically significant (P = 0.033). There were 11 cases (28.9%) in radiotherapy group and 18 cases (45.0%) in radiotherapy group. There was no significant difference between the two groups (P = 0.143). The survival rates of one-year and three-year radiotherapy group were 95.0% and 74.8%, respectively. The radiotherapy group was 90.0% and 59.5% respectively. There was no significant difference between the two groups (P = 0.168). Conclusions Radiotherapy combined with DDP can reduce the residual tumor rate and improve the local control rate.