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目的:探讨具有调节细胞凋亡作用的生存素、bcl-2和p53蛋白在卵巢上皮性肿瘤中表达及意义。方法:用免疫组织化学方法检测该院2002～2007年卵巢良性上皮性肿瘤(22例)、交界性肿瘤(19例)以及恶性肿瘤(34例)中生存素、bcl-2及突变型p53蛋白的表达情况,并以正常卵巢组织(12例)作为对照。结果:生存素及突变型p53在卵巢良性上皮性肿瘤中表达的阳性率低于恶性肿瘤组,而bcl-2在3组中的表达则无统计学意义。生存素、bcl-2及p53的表达强度与恶性肿瘤的临床期别无相关性,但随肿瘤恶性程度升高,多个标记物同时表达的现象增加。生存素的表达和突变型p53表达有关。结论:生存素、bcl-2及突变型p53与卵巢上皮性肿瘤形成有关,其中生存素及突变型p53与恶性肿瘤发生有关,且二者表达有相关性。恶性卵巢上皮性肿瘤的发生可能是多基因共同作用的结果。
OBJECTIVE: To investigate the expression and significance of survivin, bcl-2 and p53 in epithelial ovarian tumors with apoptosis-inducing effect. Methods: The expressions of survivin, bcl-2 and mutant p53 protein in ovarian benign epithelial tumors (22 cases), borderline tumors (19 cases) and malignant tumors (34 cases) from 2002 to 2007 were detected by immunohistochemistry. The expression of normal ovarian tissue (12 cases) as a control. Results: The positive rate of survivin and mutant p53 expression in benign ovarian epithelial tumors was lower than that in malignant tumors, while the expression of bcl-2 in 3 groups was not statistically significant. The expressions of survivin, bcl-2 and p53 were not correlated with the clinical stage of malignant tumors. However, with the increase of malignancy, the simultaneous expression of multiple markers increased. Survivin expression and mutant p53 expression. CONCLUSION: Survivin, bcl-2 and mutant p53 are associated with ovarian epithelial neoplasia. Survivin and mutant p53 are associated with the occurrence of malignant tumor, and the expression of survivin, bcl-2 and p53 are correlated. The occurrence of malignant ovarian epithelial tumors may be the result of multi-gene interaction.