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目的 :探索p16、p15基因与宫颈癌发生发展的关系。方法 :应用免疫组化ABC方法对 36例宫颈癌组织中p16、p15基因表达产物进行检测。结果 :p16、p15基因产物的阳性表达率分别为 6 3 9%(2 3/ 36 )、55 6 % (2 0 / 36 ) ,二者的表达率与宫颈癌病理类型无显著关系 (P >0 0 5) ,而与宫颈癌的浸润、转移及病人的生存期显著相关 (P <0 0 5)。结论 :p16、p15基因表达产物可以作为判断宫颈癌预后的指标。
Objective: To explore the relationship between p16, p15 gene and the development of cervical cancer. Methods: Immunohistochemical ABC method was used to detect the expression of p16 and p15 gene in 36 cases of cervical cancer. Results: The positive rates of p16 and p15 gene products were 63.9% (2/36) and 55 6% (20/36), respectively. The positive rates of p16 and p15 were not related to the pathological types of cervical cancer (P> However, it was significantly associated with invasion, metastasis and survival of patients with cervical cancer (P <0.05). Conclusion: The expression of p16 and p15 genes can be used as an index to judge the prognosis of cervical cancer.