采用生物信息学预测对人AAA+(ATPases associated with diverse cellular Activities)ATP酶家族成员Ruvbl1蛋白质的理化性质、蛋白质同源性、跨膜区域、核定位序列及信号肽、亲/疏水性,蛋白质高级结构、蛋白质间相互作用、GO注释进行预测分析。人Ruvbl1蛋白有456个氨基酸,等电点为6.02,有核定位序列,无信号肽,蛋白质具亲水性且高度保守;二级结构存在21个α螺旋和10个β折叠,相互作用蛋白及GO注释提示其主要在细胞核中发挥功能。人Ruvbl1蛋白是DNA解螺旋的关键酶,通过解螺旋DNA为基因的同源重组以及DNA损伤修复提供结构基础。 Bioinformatics was used to predict the physicochemical properties, protein homology, transmembrane region, nuclear localization sequence and signal peptide, pro-hydrophobicity, and protein high-order structure of Ruvbl1 protein of human AAA + ATPase family members. , Protein interactions, GO annotation prediction analysis. The human Ruvbl1 protein is 456 amino acids with an isoelectric point of 6.02. It has a nuclear localization sequence, no signal peptide, and the protein is highly conserved. The secondary structure has 21 α-helices and 10 β-sheets, interacting proteins and GO notes suggest that it functions primarily in the nucleus. Human Ruvbl1 protein is the key enzyme of DNA helicase, which provides the structural basis through the homologous recombination of helicase DNA and DNA damage repair.