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卵泡刺激素(FSH)是一种由脑垂体合成并分泌的激素,与支持细胞膜上的FSH受体(FSHR)结合,提高支持细胞合成雄激素结合蛋白的水平,同时分泌抑制素,在生精过程中起到至关重要的作用。随着DNA测序技术的发展,检测到FSH基因单核苷酸多态性(SNP)rs10835638和FSHR基因SNPs rs6165,rs6166,rs1394205,这些SNPs可能直接影响FSH表达水平和FSHR的活性,在男性主要表现为精子发生障碍。本文综述FSH及FSHR基因多态性与男性精子发生的相关性。
Follicle stimulating hormone (FSH) is a hormone synthesized and secreted by the pituitary that binds to the FSH receptor (FSHR) on the supporting cell membrane to increase the level of the androgen-binding protein that the supporting cell synthesizes and at the same time secrete inhibin, The process plays a crucial role. With the development of DNA sequencing technology, single nucleotide polymorphism (SNP) rs10835638 of FSH gene and rs6165, rs6166, rs1394205 of FSHR gene were detected. These SNPs may directly affect the FSH expression level and the activity of FSHR. Sperm barriers. This article reviews the correlation between FSH and FSHR gene polymorphisms and spermatogenesis in men.