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目的 :观察国产重组酵母乙型肝炎疫苗 (YDV)阻断乙型肝炎病毒母婴传播的免疫持久性及探讨母亲为 HBs Ag和HBe Ag双阳性 (乙肝双阳性 )婴儿的免疫方法。方法 :对母亲乙肝双阳性的 97例婴儿 ,按 0、1、6个月程序 ,接种国产 YDV,5 μg/次。于免疫后 9个月和 1～ 6岁每年各采血 1次 ,用 RIA法检测 HBs Ag和抗 - HBs。结果 :共有 1 2例 HBs Ag阳性儿 ,HB-s Ag阳性率、再感染率和母婴传播阻断率分别为 1 2 .37% (1 2 / 97)、3.4 1 % (3/ 88)和 85 .4 4 %。免疫后 1～ 6年的抗 - HBs(>1 0IU/ L)阳性率分别为 83.95 % (6 8/ 81 )、82 .86 % (5 8/ 70 )、71 .1 9% (4 2 / 5 9)、6 4 .2 9% (2 7/ 4 2 )、5 0 .0 0 % (1 8/ 36 )和 4 0 .0 0 % (1 4 /35 )。结论 :国产 YDV对乙型肝炎病毒母婴传播 6年内仍有较好的阻断效果 ,但保护性抗体已下降到 4 0 %。母亲乙肝双阳性的婴儿 3岁半需加强免疫 ,1岁时对抗 - HBs<30 IU/ L 的无、弱应答儿复种效果会更好。
OBJECTIVE: To observe the immune persistence of domestic recombinant yeast hepatitis B vaccine (YDV) in blocking the transmission of hepatitis B virus (HBV) from mother to child and to explore the immunization method of the mother with HBs Ag and HBe Ag double positive (hepatitis B double positive) infants. Methods: Ninety-seven infants who had a positive hepatitis B virus status were vaccinated with domestic YDV at 0, 1 and 6 months. Blood samples were taken at 9 months after immunization and 1 to 6 years old respectively. HBs Ag and anti-HBs were detected by RIA. Results: The positive rates of HBsAg, re-infection and mother-to-child transmission were 12.37% (12/97) and 3.4% (3/88) in 12 HBsAg positive children respectively. And 85.44%. The positive rates of anti-HBs (> 10 IU / L) at 1 to 6 years after immunization were 83.95% (68/81), 82.86% (58/70) and 71.19% (4 2 / 5 9), 6 4 .2 9% (2 7/4 2), 50.0% (18/36) and 40.0% (14/35). CONCLUSION: Domestic YDV still has good blocking effect on hepatitis B virus within 6 years, but the protective antibody has dropped to 40%. Mother hepatitis B-positive infants 3 and a half years need to strengthen the immune, 1-year-old fight - HBs <30 IU / L of no, weak responders multiplying effect will be better.