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氟尿嘧啶(fluorouracil,5-Fu)为常用的抗肿瘤药物,近来发现其在治疗某些眼科疾患中,也有较好疗效,结合文献介绍如下。 1 抑制眼内纤维组织增生 万迪玲报道有些患眼在内眼手术以后发生纤维蛋白渗出,严重者可形成纤维团块或膜状物,导致视网膜表面和玻璃体内收缩性膜状物形成,引起视网膜脱离和变形,严重影响手术效果。用氟尿嘧啶0.4m1加0.9％氯化钠溶液0.6ml眼周注射,可抑制玻璃体纤维组织增生,提高视力。机制:该药能影响细胞DNA的生物合成,导致细胞损伤或死亡,对成纤维细胞有杀伤作用,能抑制眼内纤维组织的增生和减少眼内新生血管的发生。
Fluorouracil (5-Fu) is a commonly used anti-tumor drug, and has recently been found to have good therapeutic efficacy in the treatment of certain ophthalmic diseases. The literature is described below. 1 inhibition of intraocular fibrosis Wande Ling reported that some patients with ocular fibrin exudation after ocular surgery, severe cases can form fiber clumps or membranous, resulting in the formation of the retina surface and intravitreal contractile membrane, Cause retinal detachment and deformation, seriously affecting the surgical results. Fluorouracil 0.4m1 plus 0.9% sodium chloride solution 0.6ml eye injection, can inhibit the proliferation of vitreous fiber and improve visual acuity. Mechanism: The drug can affect cell DNA biosynthesis, leading to cell damage or death, killing of fibroblasts, can inhibit the proliferation of intraocular fibrous tissue and reduce the occurrence of intraocular neovascularization.