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INTRODUCTIONrnBone remodeling is a lifelong process in vertebrates that relies on the balance between bone formation by osteoblasts and bone resorption by osteoclasts.1–3 When the balance is disrupted, as is seen in chronic inflammatory diseases, such as rheumatoid arthritis and ankylosing spondylitis, abnormal bone loss and osteoporotic fractures often occurs.4 Studies have reported that increases in the pro?inflammatory cytokines during chronic inflammation make an important contribution to bone loss by promoting osteoclast differentiation and/or inhibiting osteoblast maturation and function.1,4 Thus, strategies designed to inhibit pro?inflammatory activities hold promise in promoting bone regeneration and preventing inflammation?induced osteoporosis.