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中枢5-羟色胺[1a、2]和内源性吗啡样物质[3、4]已被证明是加强针刺镇痛的二个重要因素;而中枢去甲肾上腺素(NE)神经递质,从迄今所获得的资料看,倾向于认为中枢NE对抗针刺镇痛[5、6],但也有报告认为其作用不肯定[2],或相反有加强针刺镇痛的作用[7]。这与脑内NE和受体作用的复杂性有关。鉴于脑内NE可作用于α、β等不同的受体,中枢NE通过α受体对抗针效[8、9],通过β受体加强针效[8、10]。但β受体又分为β_1受体和β_2受体;目前关于中枢β_1、β_2受体的作用尚未见报道。我们选用β_2受体激动剂氨哮素(Clenbuterol,简称CL)从外周和中枢两方面观察其对电针镇痛的影响,并对β_2受体的作用进行分析。
Central serotonin [1a, 2] and endogenous morphine-like substances [3,4] have been shown to be two important contributors to acupuncture analgesia; central norepinephrine (NE) Data obtained to date have tended to suggest that central NE is resistant to acupuncture analgesia [5,6], but there are also reports of uncertainty regarding its role [2] or concomitant acupuncture analgesia [7]. This is related to the complexity of the role of NE and receptors in the brain. Since intracerebral NE acts on different receptors such as α and β, central NE acts against acupuncture at α receptors [8,9] and acupuncture at potentials [8,10]. However, β receptors are divided into β 1 receptors and β 2 receptors. At present, the roles of β 1 and β 2 receptors in the central nervous system have not been reported yet. We used β 2 receptor agonist Clenbuterol (CL) to observe its effects on electroacupuncture analgesia from the peripheral and central aspects, and analyzed the effect of β 2 receptor.