论文部分内容阅读
目的旨在探讨慢性心力衰竭患者血清可溶性肿瘤坏死因子受体-I(sTNFR-Ⅰ)、肿瘤坏死因子-α(TNF-α)含量及其临床意义。方法慢性心衰组包括62例慢性心力衰竭患者,按心功能分级(NYHA)又分为3个组:Ⅱ级组20例,Ⅲ级组20例,Ⅳ级组22例,另设15例健康人作对照。血清sTN-FR-Ⅰ、TNF-α含量测定采用酶联免疫吸附法(ELISA)。结果结果显示慢性心力衰竭患者血清sTNFR-Ⅰ、TNF-α含量显著高于健康对照组,慢性心力衰竭患者心功能分级组间血清、sTNFR-Ⅰ、TNF-α含量也有显著差异,心功能Ⅳ级组显著高于心功能Ⅱ级组、Ⅲ级组。结论慢性心力衰竭患者血清sTNFR-Ⅰ、TNF-α含量的变化参与慢性心力衰竭致病机制,它们之间可能还有相互作用及影响,共同参与慢性心力衰竭的发病机制。
Objective To investigate the serum levels of soluble tumor necrosis factor receptor-I (sTNFR-Ⅰ) and tumor necrosis factor-α (TNF-α) in patients with chronic heart failure and their clinical significance. Methods Chronic heart failure patients included 62 patients with chronic heart failure and were divided into three groups according to their cardiac function classification (NYHA): 20 in grade Ⅱ, 20 in grade Ⅲ and 22 in grade Ⅳ, and another 15 in health Man as a control. Serum sTN-FR-Ⅰ, TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA). The results showed that the serum levels of sTNFR-Ⅰ and TNF-α in patients with chronic heart failure were significantly higher than those in healthy controls. The levels of serum sTNFR-Ⅰ and TNF-α in patients with chronic heart failure were also significantly different. Group was significantly higher than the cardiac function Ⅱ level group, Ⅲ level group. Conclusion The changes of serum sTNFR-Ⅰ and TNF-α levels in patients with chronic heart failure are involved in the pathogenesis of chronic heart failure. There may be interaction and influence between them, and they may participate in the pathogenesis of chronic heart failure.