Stargardt病是一种遗传性疾病,表现为双眼对称性的黄斑进行性萎缩,由Stargardt于1909年首先报道而命名[1]。Stargardt病常发生于近亲结婚的后代,发病人群多为6-20岁的青少年,故而又称为青少年型遗传性黄斑变性。STGD作为一种临床少见病,在疾病的早期由于临床体征不典型而易被漏诊或者误诊,本文就STGD的发病机制及临床特点作一综述。 Stargardt’s disease is a hereditary disease characterized by diminished macular atrophy of binocular symmetry, first named by Stargardt in 1909 [1]. Stargardt disease often occurs in the offspring of close relatives marriages, the incidence of mostly 6-20 years old adolescents, it is also known as adulthood-type hereditary macular degeneration. As a rare clinical disease, STGD is easily missed or misdiagnosed due to clinical signs of atypical disease. This review summarizes the pathogenesis and clinical features of STGD.