用氯喹啉治疗华枝睾吸虫病引起合并症致死二例

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例1 5岁女孩,于1962年3月中旬因粪检发现华枝睾吸虫卵而要求治疗,平时无不适症状。体检:发育正常,营养欠佳,腹稍显膨隆、柔软、无压痛,肝于剑突下3厘米处触及、质软、边缘锐利,脾未扪及。无其他特殊发现。3月20日开始用氯喹啉治疗,每日一片(每片0.25克,含基质0.15克),分二次口服。至5月5日,患儿有喉痛、咳嗽及发热,当天夜间出现呼吸困难,鼻翼搧动,唇绀、四肢发凉。检查:两侧扁桃体中度肿大及充血;两肺满布小水泡音,尤以右肺明显;心率快、心律齐、无杂音。拟诊为肺炎,遂即停服氯喹啉(除停药休息7天外,共服40天,总量10克),予以青霉素及链霉素治疗,未见好转。治疗期间病人曾呕血数次,病况日益恶化,救治无效,终于5月8日死亡。尸体解剖:右肺中叶及下叶的外1/3部分和左肺下叶均有显著的充血和水肿。胃腔内仅有20多毫升 Example 1 5-year-old girl, in mid-March 1962 for epididymal spotted eggs found in fecal examination and treatment, usually no symptoms. Physical examination: normal development, poor nutrition, slightly bulging belly bulge, soft, no tenderness, the liver touched 3 cm below the xiphoid, soft, sharp edges, spleen not palpable. No other special discovery. March 20 start with chloroquine treatment, a daily (0.25 grams per tablet, containing 0.15 grams of matrix), divided into two orally. To May 5, children with sore throat, cough and fever, breathing difficulties that day night, nose flap, cyanosis, cold limbs. Check: moderate tonsils on both sides of the enlargement and congestion; lungs covered with small blisters sound, especially the right lung obvious; fast heart rate, rhythm Qi, no noise. To be diagnosed as pneumonia, then stop taking clonazepam (except for rest for 7 days, a total of 40 days, a total of 10 grams), penicillin and streptomycin treatment, no improvement. During the treatment, the patient vomited blood several times, the condition deteriorated and the treatment was ineffective. Finally, he died on May 8. Autopsy: The middle and lower lobe of the right middle third and the lower lobe of the lower lobe have significant congestion and edema. Gastric cavity only more than 20 ml
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