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目的:探讨复方α-酮酸对糖尿病合并慢性肾功能衰竭维持性腹膜透析患者的治疗效果。方法:58例糖尿病合并肾功能衰竭维持性腹膜透析患者,随机分为2组,对照组给予常规治疗,治疗组在常规治疗情况下,口服复方α-酮酸制剂开同片,每次5片,tid,共观察12周,治疗前后分别测血肌酐、尿素氮及血清白蛋白、血红蛋白的水平。结果:2组治疗后各项指标均有明显改善(P<0.05),治疗组的白蛋白和血红蛋白水平高于对照组(P<0.05),复方α-酮酸治疗组患者的显效和总有效率高于对照组,复方α-酮酸治疗组患者治疗期间的血糖水平稳定,胰岛素使用量无增加。结论:糖尿病肾病慢性肾功能衰竭维持性腹膜透析的患者,在给予合理的营养支持及饮食结构调整后,应用常规药物加用复方α-酮酸治疗,可以改善患者的营养状况,改善残余肾脏功能,稳定血糖,提高疗效。
Objective: To investigate the therapeutic effect of compound α-keto acid on maintenance peritoneal dialysis patients with diabetes mellitus and chronic renal failure. Methods: Fifty-eight patients with diabetic peritoneal dialysis who had renal failure were randomly divided into two groups. The control group was given routine treatment. In the treatment group, , tid, were observed for 12 weeks, before and after treatment were measured serum creatinine, urea nitrogen and serum albumin, hemoglobin levels. Results: After treatment, the indexes of both groups were significantly improved (P <0.05), and the levels of albumin and hemoglobin in the treatment group were higher than those in the control group (P <0.05) The efficiency is higher than the control group, the compound α-keto acid treatment group patients during the treatment of blood glucose levels were stable, no increase in insulin use. Conclusion: Patients with diabetic nephropathy and chronic renal failure with maintenance peritoneal dialysis, after giving reasonable nutritional support and dietary adjustment, should be treated with conventional drugs plus compound α-keto acid to improve their nutritional status and improve residual renal function , Stable blood sugar, improve the curative effect.