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皮质激素或5-氨基水杨酸灌肠是治疗远端溃疡性结肠炎的首选方法。但有近1/3病人可能没有疗效,且激素直肠用药后可有40%吸收到体循环。作为替代疗法,作者用双盲对照方法,以4-氨基水杨酸(4-ASA)2g 或强的松龙20mg,每晚睡前灌肠,共6周,治疗急性溃疡性结肠炎(病灶与肛门距离少于30cm)。两组治疗前病人的基本情况、粘膜变化和临床表现相似。4-ASA组24例中的5例和强的松龙组21例中的4例因病情恶化、无进步或药物副作用而未完成疗程。
Corticosteroids or 5-amino salicylic acid enema is the preferred method of treatment of distal ulcerative colitis. However, nearly one-third of patients may have no effect, and 40% of the hormone rectum can be absorbed into the systemic circulation. As an alternative therapy, the authors treated patients with acute ulcerative colitis with a double-blind control, 2 g of 4-aminosalicylic acid (4-ASA) or 20 mg of prednisolone, for enema at bedtime for 6 weeks Anal distance less than 30cm). The basic situation of patients before treatment, mucosal changes and clinical manifestations were similar. Four of the 24 patients in the 4-ASA group and 4 of the 21 patients in the prednisolone group did not complete the course of treatment due to their deteriorating condition, progression-free or drug side effects.