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目的探讨不同分期卵巢浆液性腺癌患者组织中瘦素(leptin)mRNA的差异表达及临床价值。方法选取本院2015年6月至2016年6月收治的卵巢浆液性腺癌患者42例及同期来我院检查并明确无卵巢浆液性腺癌的42例体检者作为对照组,于超声引导下行卵巢穿刺活检术,取少量卵巢周围组织,运用PCR技术检测各组瘦素mRNA的表达情况。结果与健康对照组相比,卵巢浆液性腺癌各期患者组织中瘦素mRNA的表达均有所升高,尤以Ⅲ期瘦素mRNA的表达最为显著(P<0.05)。结论瘦素在不同分期卵巢浆液性腺癌患者组织中有不同表达,该差异表达可能与卵巢浆液性腺癌分化程度相关。
Objective To investigate the differential expression and clinical value of leptin mRNA in different stages of ovarian serous adenocarcinoma. Methods Forty-two patients with ovarian serous adenocarcinoma admitted to our hospital from June 2015 to June 2016 and 42 patients with ovarian serous adenocarcinoma who were examined in our hospital during the same period were selected as the control group. Under ultrasound-guided ovarian puncture Biopsy, take a small amount of ovarian tissue around the use of PCR detection of leptin mRNA expression in each group. Results Compared with healthy control group, the expression of leptin mRNA increased in all stages of ovarian serous adenocarcinoma, especially the expression of leptin mRNA in stage Ⅲ was the most significant (P <0.05). Conclusion Leptin has different expression in different stages of ovarian serous adenocarcinoma, which may be related to the differentiation of ovarian serous adenocarcinoma.