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宫颈癌是常见的妇科恶性肿瘤.流行病学研究认为其原因是多方面的,包括性行为、孕产次、吸烟及性疾患.而最近研究着重强调病毒感染、细胞遗传及免疫功能改变对宫颈癌发病的影响.本文着重介绍HPV感染、染色体异常及免疫功能改变在宫颈癌发生中的作用.病毒感染关于病毒感染致癌的理论畅行于50年代末.Fouglio和Ferenczy通过对宫颈癌病原学分析后指出,宫颈癌(至少是鳞癌)可能是通过性接触造成的感染而致,并初步证实病原为Ⅱ型单纯疱疹病毒(HSV-2).Graham等对181例宫颈不典型增生、原位癌及浸润型宫颈癌行HSV-2抗体放射免疫测定(RIA),与130例进
Cervical cancer is a common gynecological malignancy. Epidemiological studies believe that its causes are many, including sexual behavior, maternal births, smoking and sexually transmitted diseases. Recent studies have emphasized the virus infection, cytogenetic and immune function changes on the cervix Cancer incidence.This article focuses on the role of HPV infection, chromosomal abnormalities and changes in immune function in the occurrence of cervical cancer.Viral infection On the theory of viral infection oncogenic smooth in the late 50s.Fouglio and Ferenczy through cervical cancer etiology analysis Pointed out that cervical cancer (at least squamous cell carcinoma) may be caused by infection caused by sexual contact and initially confirmed that the pathogen is herpes simplex virus type Ⅱ (HSV-2) .Graham et al on 181 cases of cervical dysplasia, carcinoma in situ And invasive cervical cancer line HSV-2 antibody radioimmunoassay (RIA), with 130 cases into