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目的:观察自拟祛毒活络汤联合苯溴马隆治疗痛风急性期高尿酸血症的临床效果。方法:纳入74例痛风急性期高尿酸血症患者,按随机数字表法分为对照组与治疗组,各37例,对照组单用苯溴马隆治疗,观察组加用自拟祛毒活络汤,监测两组治疗前后血尿酸(UA)、血肌酐(SCr)、24 h尿蛋白定量等指标的变化,观察治疗前后两组关节功能的变化情况,记录两组症状改善情况。结果:(1)治疗组总有效率为91.89%,明显高于对照组的62.16%,对比差异有统计学意义(P<0.05)。(2)治疗后,两组症状积分均明显降低,治疗组红肿、疼痛、发热、活动受限等积分降低幅度高于对照组(P<0.05)。(3)治疗后,两组尿酸排泄指标均有改善,治疗组UA、24 h尿蛋白定量、Scr均明显降低,幅度高于对照组(P<0.05)。(4)治疗后,两组关节压痛评分、肿胀个数及关节活动指数均有所改善,治疗组关节压痛评分降低显著、关节肿胀个数减少、关节活动指数改善,幅度均优于对照组(P<0.05)。结论:自拟祛毒活络汤联合苯溴马隆治疗痛风急性期高尿酸血症,疗效确切,患者关节功能改善明显,血尿酸指标改善显著。
Objective: To observe the curative effect of self-made Quxu Huoxu Decoction combined with benzbromarone in the treatment of acute gout hyperuricemia. Methods: A total of 74 patients with acute gout hyperuricemia were enrolled in this study. According to random number table, the patients were divided into control group and treatment group, 37 cases in each group. The control group was treated with benzbromarone alone. The observation group was treated with self- The changes of serum uric acid (UA), serum creatinine (SCr) and 24 h urinary protein in two groups before and after treatment were monitored. The changes of joint function were observed before and after treatment. The symptom improvement was recorded. Results: (1) The total effective rate of the treatment group was 91.89%, which was significantly higher than that of the control group (62.16%), the difference was statistically significant (P <0.05). (2) After treatment, the symptom scores of both groups were significantly decreased. The reduction of integrals in the treatment group such as inflamed, painful, fever and limited activity was lower than that of the control group (P <0.05). (3) The uric acid excretion index of both groups improved after treatment. The urine UA and 24 h urinary protein in the treatment group were significantly lower than those in the control group (P <0.05). (4) After treatment, the joint tenderness score, the number of swelling and the joint activity index both improved. The joint tenderness score of the treatment group decreased significantly, the number of joint swelling decreased, the joint activity index improved, the amplitude was better than that of the control group P <0.05). Conclusion: The self-made Quxuhuoxu Decoction combined with benzbromarone in the treatment of acute gout hyperuricemia, the curative effect is definite, the patients’ joint function is obviously improved and the index of serum uric acid is improved obviously.