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对24例慢性乙型肝炎(下称慢乙肝)患者于肝穿同日留取血清,分别进行肝组织HBV-DNA、血清HBV-DNA定量检测及血清HBeAg量的测定, 并比较肝组织与血清HBV-DNA定量的差异,分析肝组织HBV-DNA定量与血清HBV-DNA定量、HBeAg量及肝功能指标之间的相关性,比较各型慢乙肝肝组织HBV-DNA定量的差异。结果显示,肝组织HBV-DNA定量明显高于血清HBV-DNA定量,二者的对数值呈显著相关;肝组织HBV-DNA定量与HBeAg量呈中度相关,与血清谷丙转氨酶(ALT)、总胆红素(TBIL)、白蛋白与球蛋白之比(A/G)无关,各型慢乙肝肝组织HBV-DNA定量无统计学差异。提示肝组织HBV-DNA定量较血清HBV-DNA定量、HBeAg量更能反映肝内HBV复制水平,具有重要的临床意义。
Serum levels of HBV-DNA, serum HBV-DNA and serum HBeAg were measured in 24 patients with chronic hepatitis B (chronic hepatitis B) on the same day after liver transplantation. -DNA quantitative analysis of liver tissue, quantitative analysis of HBV-DNA and serum HBV-DNA quantitative, HBeAg and liver function index correlation between the various types of chronic hepatitis B liver HBV-DNA quantitative differences. The results showed that the quantification of HBV-DNA in liver tissue was significantly higher than that of serum HBV-DNA, and the logarithm of the two was significantly correlated. HBV-DNA in liver tissue was moderately correlated with the amount of HBeAg, Total bilirubin (TBIL), albumin and globulin ratio (A / G) has nothing to do, each type of chronic hepatitis B liver HBV-DNA quantitative no significant difference. It is suggested that the quantification of HBV-DNA in liver tissue is more than that of serum HBV-DNA, and the quantity of HBeAg can reflect the level of intrahepatic HBV replication, which has important clinical significance.