论文部分内容阅读
透皮吸收制剂按照被动扩散方式释放药物,只有少数药物经透皮可以达到治疗需要量.必须给这类制剂提供能量使药物主动释放和通过皮肤屏障转运至全身.电泳控制系统可能成为特别重要的系统,有可能引导带电荷物质在电场中迁移达到药物主动转运.本文目的是研制一种抗组胺药局部应用于皮肤的新系统,适于短期治疗,例如虫咬引起的急性皮肤刺激,用药后很快就能减轻症状.因此,设计一种用于电泳释放药物透皮系统的电子指示器就显得特别重要.苯海拉明凝胶:230mg盐酸苯海拉明,345mg琼脂,4.6g甘油加到23g纯水中,均匀混合,加热溶解,冷却至约40℃,取2.3g倾入圆形塑料容器(内径20mm,深4mm)内.凝胶体上表面与薄铝极接触,接
Transdermal formulations deliver drugs in a passive diffusion mode, and only a small percentage of the drug can be delivered via the transdermal skin.The energy must be given to such formulations to allow the active release of the drug and transport through the skin barrier to the body Electrophoretic control systems may become particularly important System, it is possible to direct the migration of charged substances in the electric field to achieve active drug delivery.The purpose of this paper is to develop a new system for topical application of antihistamines to the skin, which is suitable for short-term treatments such as acute skin irritation caused by insect bites, Soon after the symptoms can be alleviated.Therefore, the design of a kind of electrophoresis for the release of drug transdermal system electronic indicator is particularly important.Denilamine gel: 230mg diphenhydramine hydrochloride, 345mg agar, 4.6g of glycerol Added to 23g of pure water, uniformly mixed, heated to dissolve, cooled to about 40 ℃, 2.3g poured into a circular plastic container (inner diameter 20mm, 4mm deep.) The upper surface of the gel contact with the thin aluminum, then