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目的:研究肝毒清滴丸的保肝、镇痛和抗炎作用,并与健肝乐颗粒的药理作用进行比较。方法:通过小鼠急性肝损伤实验,观察对比肝毒清滴丸和健肝乐颗粒的保肝作用;通过小鼠耳肿胀、毛细血管通透性试验,观察对比肝毒清滴丸和健肝乐颗粒对急性炎症的作用;通过小鼠扭体和热板试验,观察对比肝毒清滴丸和健肝乐颗粒的镇痛作用。结果:肝毒清滴丸能显著降低小鼠血清中GPT和GOT的含量(P<0.01),与健肝乐颗粒比较,低、中剂量组差异有显著性(P<0.01);能显著降低MDA和升高SOD,差异有显著性(P<0.01或P<0.05),与健肝乐颗粒比较,升高SOD差异有显著性(P<0.01),降低MDA差异有显著性(P<0.01或P<0.05);肝毒清滴丸能较强抑制二甲苯所致小鼠耳肿胀,且可剂量依赖性缓解小鼠腹腔渗出性炎性作用,与健肝乐颗粒比较,差异有显著性(P<0.05);对小鼠热刺激引起的疼痛具有良好的镇痛作用,且能减少醋酸致痛小鼠的扭体次数,与健肝乐颗粒比较,差异有显著性(P<0.01)。结论:肝毒清滴丸具有保肝、镇痛和抗炎作用,效果优于健肝乐颗粒。
Objective: To study the hepatoprotective, analgesic and anti-inflammatory effects of Ganduqing dripping pills and to compare the pharmacological effects of Jianganle pills. Methods: Acute liver injury in mice was observed by comparing the hepatoprotective effect of Ganshuqing dripping pills and Jianganle granules. The ear swelling and capillary permeability test in mice were compared to observe the effect of Ganshuqing dripping pills and Jianganle granules On the role of acute inflammation; through the writhing and hot plate test in mice to observe the analgesic effect of Ganshuqing dripping pills and Jianganle granules. Results: Ganduqing dripping pills can significantly reduce the content of GPT and GOT in serum of mice (P <0.01). Compared with Jianganle granules, the difference of GPT and GOT was significant (P <0.01) (P <0.01 or P <0.05). Compared with Jianganle Granules, SOD increased significantly (P <0.01) and decreased MDA (P <0.01) Or P <0.05). Hepatic serum dripping pills could strongly inhibit xylene-induced ear swelling in mice and relieve the peritoneal exudative inflammatory effect in a dose-dependent manner, which was significantly different from that of Jianganle granules (P <0.05). It has a good analgesic effect on pain caused by heat stimulation in mice and can reduce writhing times in mice induced by acetic acid. Compared with Jianganle granules, the difference was significant (P <0.01) ). Conclusion: Ganduqing dripping pills have the functions of protecting the liver, relieving pain and relieving inflammation, and the effect is better than Jianganle granules.