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目的探讨枸橼酸铋雷尼替丁、左氧氟沙星、阿莫西林三联一周疗法,根除幽门螺杆菌(Hp)的疗效及安全性。方法选择100例Hp阳性的慢性胃炎和消化性溃疡患者,随机分为两组,治疗组采用枸橼酸铋雷尼替丁350 mg、左氧氟沙星200 mg、阿莫西林1000 mg,均为每日2次(早、晚),疗程l周。对照组采用奥美拉唑20 mg、克拉霉唑500 mg、阿莫西林1000 mg,均为每日2次(早、晚),疗程l周,4周后复查Hp。结果治疗组Hp根除率92%,对照组Hp根除率82%,差异无统计学意义(P>0.05)。结论枸橼酸铋雷尼替丁、左氧氟沙星、阿莫西林三联疗法Hp根除率高,副作用少而轻,患者依从性好,值得临床推广使用。
Objective To investigate the efficacy and safety of triple therapy of ranitidine bismuth citrate, levofloxacin and amoxicillin in the eradication of Helicobacter pylori (Hp). Methods 100 cases of Hp-positive chronic gastritis and peptic ulcer patients were randomly divided into two groups, the treatment group ranitidine bismuth citrate 350 mg, levofloxacin 200 mg, amoxicillin 1000 mg, were 2 Times (morning and evening), course of treatment l weeks. In the control group, omeprazole 20 mg, clarithromycin 500 mg and amoxicillin 1000 mg were administered twice a day (morning and evening). The course of treatment was 1 week and the Hp was examined after 4 weeks. Results The Hp eradication rate was 92% in the treatment group and 82% in the control group, with no significant difference (P> 0.05). Conclusion Ranitidine bismuth citrate, levofloxacin, amoxicillin triple therapy Hp eradication rate, less side effects and light, good compliance, worthy of clinical promotion and use.