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目前已研制出糖肽类抗生素达50多种,但能够用于临床的只有万古霉素一种。新糖肽抗生素替考拉宁(Teicoplanin)在欧洲已进行了广泛的临床试验,而美国最近才开始对其进行试用。糖肽类抗生素具有共同的抗菌谱(仅对G~+菌有效),但它们的抗菌效力和药理作用有所不同。一、化学及其分类所有糖肽类抗生素几乎都是由7种氨基酸构成的肽类物质,其中有5种肽属于芳香氨基酸,并且每一种糖肽抗生素均含此5种芳香氨基酸,其它两种在1位和3位的氨基酸,有助于将糖肽类抗生素分成三种类型:万
At present, over 50 kinds of glycopeptide antibiotics have been developed, but only vancomycin can be used clinically. The new glycopeptide antibiotic Teicoplanin has undergone extensive clinical trials in Europe, and the United States has only recently begun trials of it. Glycopeptide antibiotics have a common antibacterial spectrum (only G ~ + bacteria effective), but their antibacterial efficacy and pharmacological effects are different. First, the chemical and its classification All glycopeptide antibiotics are almost all peptides composed of seven kinds of amino acids, of which five peptides belong to aromatic amino acids, and each glycopeptide antibiotics contain these five kinds of aromatic amino acids, the other two Amino acids at 1 and 3 help to classify glycopeptide antibiotics into three types: