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目的：探讨ＮＯ２ 致急性肺损伤机理。方法：大鼠静式吸入染毒，观测肺组织病理变化及肺泡灌洗液中蛋白和ＬＤＨ 含量，同时测定肺组织抗氧化物及丙二醛（ＭＤＡ）的含量。结果：大鼠吸入ＮＯ２ 后，肺组织明显损伤，同时ＧＳＨ－ＰＸ、ＳＯＤ、维生素Ｅ、总巯基含量显著降低，ＭＤＡ 含量也明显下降，肺损伤越重，各指标下降越明显，随着肺损伤的修复，各指标也恢复正常。结论：ＮＯ２ 染毒后肺组织抗氧化能力下降可能在其致急性肺损伤中起一定作用
Objective: To investigate the mechanism of NO2-induced acute lung injury. Methods: The rats were inhaled by inhalation, the pathological changes of lung tissue and the content of LDH in alveolar lavage fluid were observed. At the same time, the contents of antioxidants and malondialdehyde (MDA) in lung tissue were measured. Results: After inhaled NO2, the lung tissue was significantly damaged. At the same time, the content of GSH-PX, SOD, vitamin E and total sulfhydryl group was significantly decreased, MDA content was also significantly decreased, the lung injury was more serious, The repair, the indicators are back to normal. Conclusion: The decreased antioxidant capacity of lung tissue after NO2 exposure may play a role in its acute lung injury