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前列腺癌发生发展与多种基因的异常表达有关,其癌变的形成和发展与多种癌基因的激活和抑癌基因的失活或缺失密切相关。本文综述了几种与前列腺癌关系密切的癌基因和抑癌基因的作用机制,癌基因主要有bcl-2基因、c-myc基因r、as基因、HER-2/neu、前列腺癌诱导基-因1(PTI-1)和HPG1等6种癌基因;抑癌基因包括PTEN、p16、p53、Rb、KLF6和RASSFIA等6种抑癌基因。这些癌基因和抑癌基因在前列腺癌发展过程中的表达量的变化和肿瘤分级、预后相关。
The development and progression of prostate cancer are related to the abnormal expression of many genes. The formation and development of cancer are closely related to the activation of many oncogenes and inactivation or deletion of tumor suppressor genes. This review summarizes several mechanisms of oncogenes and tumor suppressor genes that are closely related to prostate cancer. The oncogenes mainly include bcl-2 gene, c-myc gene r, as gene, HER-2 / neu, 6 kinds of oncogenes such as PTI-1 and HPG1; and tumor suppressor genes include 6 tumor suppressor genes PTEN, p16, p53, Rb, KLF6 and RASSFIA. Changes in the expression of these oncogenes and tumor suppressor genes in the development of prostate cancer are correlated with tumor grade and prognosis.