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目的:探讨双水平气道正压通气(BiPAP)在中重度支气管哮喘治疗中的作用。方法:选择64例急性中重度支气管哮喘患者随机分为常规治疗基础上辅助用BiPAP无创通气组32例与常规治疗对照组32例,监测其治疗前、治疗后2、12、72h血气变化,治疗前、治疗后72h肺功能(FEV1、FEV1/FVC%、PEF)及部分生理指标(HR、RR、MAP)变化,观察临床情况的变化及治疗转归,对结果进行对比分析。结果:BiPAP无创通气组的PH、PaO2、PaCO2及肺功能等指标明显改善(P<0.01,P<0.05)。结论:BiPAP能明显改善中重度支气管哮喘患者的低氧血症、高碳酸血症及肺功能,其疗效明显优于常规治疗方法。
Objective: To explore the role of bi-level positive airway pressure (BiPAP) in the treatment of moderate-severe bronchial asthma. Methods: Sixty-four patients with acute moderate-to-severe bronchial asthma were randomly divided into routine treatment based on 32 cases of BiPAP non-invasive ventilation assisted by conventional therapy and 32 cases of conventional treatment control group. The changes of blood gas before treatment, 2,12,72h after treatment were monitored, (FEV1, FEV1 / FVC%, PEF) and some physiological indexes (HR, RR, MAP) before and 72 hrs after treatment. The change of clinical situation and treatment outcome were observed and the results were compared. Results: The parameters of PH, PaO2, PaCO2 and pulmonary function of BiPAP non-invasive ventilation group were significantly improved (P <0.01, P <0.05). Conclusion: BiPAP can significantly improve the hypoxemia, hypercapnia and pulmonary function in patients with moderate-severe bronchial asthma, and its efficacy is obviously better than the conventional treatment.