自从1930年Streng等描写了血清中免疫胶固素(immunoconglutinin)(IK)的活性后,多数认为是由于感染微生物、免疫原或自身抗原引起抗原抗体复合物所形成的抗体。这种免疫复合物,固定了补体,使补体激活,从而改变了成分,成为免疫原,并刺激机体产生IK。 IK的增加,对细菌感染的免疫力和促使菌血症的终止,在慢性细菌感染时,血清IK滴度也有所增加。但有关在慢性病毒性感染中,IK反应了解得还很少。本研究着重 Since Streng et al. Described the activity of immunoconglutinin (IK) in serum in 1930, most are thought to be antibodies formed by antigen-antibody complexes due to infection with microorganisms, immunogens or autoantigens. This immune complex, which fixes the complement, activates the complement, altering the composition, becoming an immunogen, and stimulating the body to produce IK. Increased IK, immunity to bacterial infections, and termination of bacteremia also have increased serum IK titers during chronic bacterial infections. However, IK response is still poorly understood in chronic viral infections. This research focuses